Mambalgin-2

• Description:

  Mambalgin-2 (Mamb-2) is an acid-sensitive ion channels (ASICs) inhibitor and a venom peptide. Mambalgin-2 can be obtained from the venom of the African black mamba. Mambalgin-2 can be used in the study of pain and neurological diseases[1].

• Product Name Alternative:

  Mamb-2

• UNSPSC:

  12352209

• Target:

  Sodium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mambalgin-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (C (N) CC (C) C) NC (C (N[C@H] (C (NC (C (N[C@H] (C (NC (C (NCC (NC (C (NC (C (N[C@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@H] (C (NC (C (NC (C (NC (C (NC (C (N[C@H]1CC2=CC=CC=C2) =O) CCCCN) =O) CCSC) =O) CC (O) =O) =O) CCCNC (N) =N) =O) CC3=CNC=N3) =O) CS) =O) [C@H] (C) O) =O) C (C) C) =O) C (C) C) =O) CCCCN) =O) =O) CC4=CNC=N4) =O) CCC (N) =O) =O) CC5=CC=CC=C5) =O) CSSCC (NC1=O) C (NC (C (NC (C (NC (C (NC (C (NCC (NC (C (N6[C@H] (C (NC (C (NC (C (NC (C (NC (C (NC (C (NC (C (NC (C (NC (C (NC (C (NCC (NC (C (NC (C (NC (C (NC (C (NC (C (NC (C (NC (C (N[C@@H] (C (NC (C (NC (C (NC (C (NC7CCCCN) =O) CC (N) =O) =O) CC (N) =O) =O) CCC (O) =O) =O) C (C) O) =O) CCC (O) =O) =O) CO) =O) CSSCC (NC7=O) C (NC (C (NC (C (NC (C (NC (C (NC8CCCNC (N) =N) =O) CC (O) =O) =O) C (C) O) =O) CO) =O) CSSCC (NC8=O) C (NC (C (NC (C (O) =O) CCCCN) =O) CC (N) =O) =O) =O) =O) CO) =O) CO) =O) CO) =O) CS) =O) =O) CCC (N) =O) =O) CC (C) C) =O) C (CC) C) =O) CC (C) C) =O) CCCCN) =O) CC (C) C) =O) CC (N) =O) =O) CCCNC (N) =N) =O) CC9=CC=CC=C9) =O) CCC6) =O) CCSC) =O) =O) C (C) O) =O) CC (N) =O) =O) CC%10=CNC=N%10) =O) CC%11=CC=C (O) C=C%11) =O) =O) CCCCN

• Molecular Formula:

  C272H431N85O83S10

• Molecular Weight:

  6540.50

• References & Citations:

  [1]Salinas M, et al. Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a. J Biol Chem. 2014 May 9;289 (19) :13363-73.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported