MEN 11270

CAT: 0931-MF-0044891Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0044891Size:5 mg
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CAS Number
235082-52-7
Target
Bradykinin Receptor
Related Pathways
GPCR/G Protein
Bioactivity
Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3) ; conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5) .
Smiles
O=C1N2[C@@]3([C@](C[C@]2(C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC[C@H](NC([C@H](CC4=CC=CS4)NC(CNC(=O)[C@H]5N(C(=O)[C@H]6N(C([C@@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCC6)C[C@H](O)C5)=O)=O)C(=O)N7[C@@]1(CC=8C(C7)=CC=CC8)[H])[H])(CCCC3)[H])[H]
Molecular Formula
C60H90N20O11S
Molecular Weight
1299.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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