PHM-27 (human)

• Target :

  CGRP Receptor

• Related Pathways :

  Neuroscience|||GPCR/G Protein

• Bioactivity :

  Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM) . Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic ?-islets display enhanced glucose-induced insulin secretion.

• Smiles :

  [C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)N)=O)C)=O)CC(O)=O)=O)=O)C(C)C)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CO)=O)C)=O)CCCCN)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)CO)=O)CCC(O)=O)=O)CC(C)C)=O

• Molecular Formula :

  C135H214N34O40S

• Molecular Weight :

  2985.44

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  87403-73-4