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CAT: 0931-TP1924Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TP1924Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
863987-12-6
Target
PKC
Related Pathways
Chromatin/Epigenetic, Cytoskeletal Signaling
Bioactivity
Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Smiles
C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC(CCCCCCCCCCCCC)=O)CO)=O)[C@H](CC)C)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C=2C=3C(NC2)=CC=CC3
Molecular Formula
C90H154N30O17
Molecular Weight
1928.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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