ZIP

• Target :

  PKC

• Related Pathways :

  Chromatin/Epigenetic|||Cytoskeletal Signaling

• Bioactivity :

  Novel, cell-permeable inhibitor of protein kinase M? (PKM?), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKM?-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 ?M) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

• Smiles :

  C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC(CCCCCCCCCCCCC)=O)CO)=O)[C@H](CC)C)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C=2C=3C(NC2)=CC=CC3

• Molecular Formula :

  C90H154N30O17

• Molecular Weight :

  1928.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  863987-12-6