KYL peptide

CAT: 0931-TP1895Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-TP1895Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

676657-00-4

Target

Ephrin Receptor

Related Pathways

Tyrosine Kinase/Adaptors

Bioactivity

KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM) ; inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM) . Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively) . Neuroprotective.

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C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)CO)=O)CC(C)C)=O)[C@H](C)C)=O)CCC1)NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CCCCN)N)=O)=O)CC(C)C)=O)CCC2)CC4=CC=C(O)C=C4)=O)C=5C=6C(NC5)=CC=CC6

Molecular Formula

C74H108N14O17

Molecular Weight

1465.75

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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KYL peptide

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