KYL peptide

• Target:

  Ephrin Receptor

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Bioactivity:

  KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 ?M) ; inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 ?M) . Prevents A?O induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively) . Neuroprotective.

• Smiles:

  C ([C@@H] (C (=O) N1[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@@H] (CC (C) C) C (O) =O) =O) CO) =O) CO) =O) CC (C) C) =O) [C@H] (C) C) =O) CCC1) NC ([C@@H] (NC (=O) [C@H]2N (C ([C@@H] (NC ([C@H] (CC3=CC=C (O) C=C3) NC ([C@H] (CCCCN) N) =O) =O) CC (C) C) =O) CCC2) CC4=CC=C (O) C=C4) =O) C=5C=6C (NC5) =CC=CC6

• Molecular Formula:

  C74H108N14O17

• Molecular Weight:

  1465.75

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  676657-00-4