KYL peptide

• Target:

  Ephrin Receptor

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Bioactivity:

  KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 ?M) ; inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 ?M) . Prevents A?O induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively) . Neuroprotective.

• Smiles:

  C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)CO)=O)CC(C)C)=O)[C@H](C)C)=O)CCC1)NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CCCCN)N)=O)=O)CC(C)C)=O)CCC2)CC4=CC=C(O)C=C4)=O)C=5C=6C(NC5)=CC=CC6

• Molecular Formula:

  C74H108N14O17

• Molecular Weight:

  1465.75

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  676657-00-4