Fz7-21

CAT: 0931-TP1263-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-TP1263-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2247635-23-8

Target

Wnt/beta-catenin

Related Pathways

Cytoskeletal Signaling, Stem Cells

Purity

0.998

Bioactivity

Fz7-21 ((Ac) -LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM) .

Smiles

C([C@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@H](CC(C)C)NC(C)=O)=O)CCC2)CO)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)CCSC)=O)[C@H](C)C)=O)=O)CS)=O)C=5C=6C(NC5)=CC=CC6

Molecular Formula

C83H114N18O23S2

Molecular Weight

1796.03

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
BA9103-5	Fz7-21
M16976	Peptide Fz7-21
CRB1001175-01	Fz7-21 - (Peptide)
M40566	Fz7-21 TFA
HY-P1454A-01	Fz7-21 (TFA)
CRB1101176-01	5-FAM-Fz7-21
CRB1101176-01	5-FAM-Fz7-21 - (Fluorescent Peptides)
BA9110-1	Fz7-21S
GTR19037085-01	Fz7-21 TFA (2247635-23-8 free base)
F6400-01	Frizzled 7 (fz7)

Fz7-21

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