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DO-264

CAT: 0804-HY-114157-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-114157-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.
CAS Number
2301866-59-9
Product Name Alternative
GCA, GCA-2, (Rac)-GCA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DO-264.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
S=C(NC1=CC=CN=C1)NC2CCN(C3=NC=CC(OC4=CC=C(OC(F)(F)F)C=C4Cl)=C3Cl)CC2
Molecular Formula
C23H20Cl2F3N5O2S
Molecular Weight
558.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Ogasawara D, et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14 (12) :1099-1108.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

DO264
CAS Number2301866-59-9
PubChem CID134813646
IUPAC Name1-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]piperidin-4-yl]-3-pyridin-3-ylthiourea
Molecular FormulaC23H20Cl2F3N5O2S
Molecular Weight558.4
XLogP6.1
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity720
SMILES
C1CN(CCC1NC(=S)NC2=CN=CC=C2)C3=NC=CC(=C3Cl)OC4=C(C=C(C=C4)OC(F)(F)F)Cl
InChI
InChI=1S/C23H20Cl2F3N5O2S/c24-17-12-16(35-23(26,27)28)3-4-18(17)34-19-5-9-30-21(20(19)25)33-10-6-14(7-11-33)31-22(36)32-15-2-1-8-29-13-15/h1-5,8-9,12-14H,6-7,10-11H2,(H2,31,32,36)
InChIKey
PIEQDBPBBQPLPL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of DO264
CAS: 2301866-59-9
CID: 134813646
Formula: C23H20Cl2F3N5O2S
MW: 558.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight558.4
XLogP36.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass557.0666859
Monoisotopic Mass557.0666859
Topological Polar Surface Area104 Ų
Heavy Atom Count36
Formal Charge0
Complexity720
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA7952-10DO-264
BD167529-01DO 264
A18881-25DO-264 25mg
A18881-5DO-264 5mg
A18881-100DO-264 100mg
A18881-10DO-264 10mg
A18881-50DO-264 50mg
A18881-1DO-264 1mg
A18881-10mM-DDO-264 10mM * 1mL in DMSO
T31559-01DO-601

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