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(-) -Butin

CAT: 0931-TN1461-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-TN1461-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
492-14-8
Target
PI3K, Nrf2, Akt
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Immunology/Inflammation
Purity
0.9807
Bioactivity
(-) -Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SOD induction via the PI3K/Akt signaling pathway.
Smiles
Oc1ccc2C(=O)C[C@H](Oc2c1)c1ccc(O)c(O)c1
Molecular Formula
C15H12O5
Molecular Weight
272.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(-)-Butin

Butin is a trihydroxyflavanone in which the three hydroxy substituents are located at positions 3', 4' and 7. It is found in Acacia mearnsii, Vernonia anthelmintica and Dalbergia odorifera and has a protective affect against oxidative stress-induced mitochondrial dysfunction. It has a role as an antioxidant, a metabolite and a protective agent. It is a member of 4'-hydroxyflavanones and a trihydroxyflavanone.

CAS Number492-14-8
PubChem CID92775
IUPAC Name(2S)-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydrochromen-4-one
Molecular FormulaC15H12O5
Molecular Weight272.25
XLogP1.8
Topological Polar Surface Area87
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity371
SMILES
C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC(=C(C=C3)O)O
InChI
InChI=1S/C15H12O5/c16-9-2-3-10-12(18)7-14(20-15(10)6-9)8-1-4-11(17)13(19)5-8/h1-6,14,16-17,19H,7H2/t14-/m0/s1
InChIKey
MJBPUQUGJNAPAZ-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of (-)-Butin
CAS: 492-14-8
CID: 92775
Formula: C15H12O5
MW: 272.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight272.25
XLogP31.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass272.06847348
Monoisotopic Mass272.06847348
Topological Polar Surface Area87 Ų
Heavy Atom Count20
Formal Charge0
Complexity371
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS3614076-01(-)-Butin
BUP22114-01Butin
GTR19155541-01(-) -Butin
HY-N6020A-01(+) -Butin
HY-N6020BR-01Butin (Standard)
HY-N6020R-01(-) -Butin (Standard)
HY-N6020AR-01(+) -Butin (Standard)

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