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Arnicolide D

CAT: 0931-TN1405-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TN1405-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
34532-68-8
Target
Apoptosis, Caspase, Akt, NF-κB, STAT, mTOR, ROS, PI3K
Related Pathways
JAK/STAT signaling, NF-κB, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis, Proteases/Proteasome, Stem Cells, Immunology/Inflammation
Purity
0.9993
Bioactivity
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.
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[H][C@@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](OC(=O)C(C)=C)[C@]1([H])[C@H](C)C(=O)O2
Molecular Formula
C19H24O5
Molecular Weight
332.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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