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6-Dehydrogingerdione

CAT: 0931-TN1171-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TN1171-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
76060-35-0
Target
Apoptosis, TNF
Related Pathways
Apoptosis
Purity
0.9698
Bioactivity
6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via a reactive oxygen species-mediated mechanism that enhances DR5 expression, up-regulates Ser-15 phosphorylation, and triggers nuclear translocation of p53. Abrogation of p53 using small interfering RNA markedly reduces 6-Dehydrogingerdione-induced DR5 and diminishes TRAIL responsiveness. ROS generation accompanies DR5 activation, and pretreatment with N-acetyl-L-cysteine significantly attenuates these apoptotic responses, confirming 6-Dehydrogingerdione acts through p53-dependent and oxidative stress-mediated apoptotic pathways.
Smiles
C(=C/C(CC(CCCCC)=O)=O)\C1=CC(OC)=C(O)C=C1
Molecular Formula
C17H22O4
Molecular Weight
290.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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