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Lupanine

CAT: 0931-TMA0805-01Size: 100 mgDry Ice: NoHazardous: No
CAT#: TMA0805-01Size: 100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
550-90-3
Target
AChR|||Potassium Channel|||Beta Amyloid
Related Pathways
Membrane transporter/Ion channel|||Neuroscience
Bioactivity
Lupanine ((+) -Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid ?-oligomers (SO-A?) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
Smiles
O=C1N2[C@@]([C@]3(C[C@@](C2)([C@]4(N(C3)CCCC4)[H])[H])[H])(CCC1)[H]
Molecular Formula
C15H24N2O
Molecular Weight
248.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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