Lupanine

• Target:

  AChR|||Potassium Channel|||Beta Amyloid

• Related Pathways:

  Membrane transporter/Ion channel|||Neuroscience

• Bioactivity:

  Lupanine ((+) -Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid ?-oligomers (SO-A?) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.

• Smiles:

  O=C1N2[C@@] ([C@]3 (C[C@@] (C2) ([C@]4 (N (C3) CCCC4) [H]) [H]) [H]) (CCC1) [H]

• Molecular Formula:

  C15H24N2O

• Molecular Weight:

  248.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  550-90-3