Protosappanin A

CAT: 0931-MF-0011771-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0011771-01Size:1 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
102036-28-2
Target
NF-?B|||HIV Protease|||I?B/IKK|||NADPH-oxidase|||IL Receptor|||JAK|||COX|||STAT|||ROS|||Interleukin|||TLR|||TNF|||NO Synthase
Related Pathways
Neuroscience|||Microbiology/Virology|||NF-?B|||Tyrosine Kinase/Adaptors|||Stem Cells|||Chromatin/Epigenetic|||Apoptosis|||Proteases/Proteasome|||JAK/STAT signaling|||Immunology/Inflammation|||Angiogenesis
Purity
>99.99%
Bioactivity
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.
Smiles
Oc1ccc-2c(OCC(=O)Cc3cc(O)c(O)cc-23)c1
Molecular Formula
C15H12O5
Molecular Weight
272.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Alternative Products

CatalogName
BUP08066-01Protosappanin A
TB0359-0020Protosappanin B
A18956-10Protosappanin A 10mg
A18956-50Protosappanin A 50mg
A18956-100Protosappanin A 100mg
A18956-1Protosappanin A 1mg
A18956-5Protosappanin A 5mg
A18956-25Protosappanin A 25mg
MBS5787775Protosappanin A dimethyl acetal
A14722-10Protosappanin B 10mg

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