NecroX-7

• Target:

  TNF|||NADPH-oxidase|||Reactive Oxygen Species|||TLR|||Interleukin|||ROS

• Related Pathways:

  Metabolism|||Immunology/Inflammation|||NF-?B|||Apoptosis

• Purity:

  0.9822

• Bioactivity:

  NecroX-7 (LC-280126) is a potent free radical scavenger and HMGB1 (high-mobility group box 1) inhibitor. It serves as an antidote to acetaminophen toxicity and exerts a protective effect by preventing HMGB1 release in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits HMGB1-induced release of TNF and IL-6 and the expression of TLR-4 and receptor for advanced glycation end products. This compound may be used for graft-versus-host disease (GVHD) research [1].

• Smiles:

  N (C1=C2C (C=C (N2) C3=CC=CC=C3) =CC (CN4CCS (=O) (=O) CC4) =C1) C5CCOCC5

• Molecular Formula:

  C24H29N3O3S

• Molecular Weight:

  439.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1120332-55-9