NecroX-7

• Target :

  TNF|||NADPH-oxidase|||Reactive Oxygen Species|||TLR|||Interleukin|||ROS

• Related Pathways :

  Metabolism|||Immunology/Inflammation|||NF-?B|||Apoptosis

• Purity :

  0.9822

• Bioactivity :

  NecroX-7 (LC-280126) is a potent free radical scavenger and HMGB1 (high-mobility group box 1) inhibitor. It serves as an antidote to acetaminophen toxicity and exerts a protective effect by preventing HMGB1 release in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits HMGB1-induced release of TNF and IL-6 and the expression of TLR-4 and receptor for advanced glycation end products. This compound may be used for graft-versus-host disease (GVHD) research [1].

• Smiles :

  N(C1=C2C(C=C(N2)C3=CC=CC=C3)=CC(CN4CCS(=O)(=O)CC4)=C1)C5CCOCC5

• Molecular Formula :

  C24H29N3O3S

• Molecular Weight :

  439.57

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1120332-55-9