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NecroX-7

CAT: 0931-T9948-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T9948-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1120332-55-9
Target
TNF|||NADPH-oxidase|||Reactive Oxygen Species|||TLR|||Interleukin|||ROS
Related Pathways
Metabolism|||Immunology/Inflammation|||NF-?B|||Apoptosis
Purity
0.9822
Bioactivity
NecroX-7 (LC-280126) is a potent free radical scavenger and HMGB1 (high-mobility group box 1) inhibitor. It serves as an antidote to acetaminophen toxicity and exerts a protective effect by preventing HMGB1 release in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits HMGB1-induced release of TNF and IL-6 and the expression of TLR-4 and receptor for advanced glycation end products. This compound may be used for graft-versus-host disease (GVHD) research [1].
Smiles
N(C1=C2C(C=C(N2)C3=CC=CC=C3)=CC(CN4CCS(=O)(=O)CC4)=C1)C5CCOCC5
Molecular Formula
C24H29N3O3S
Molecular Weight
439.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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