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(Z) -Orantinib

CAT: 0931-T9684-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T9684-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
210644-62-5
Target
PDGFR, FGFR, VEGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9805
Bioactivity
(Z) -Orantinib ((Z) -SU6668) is an effective, selective, orally active, ATP-competitive inhibitor of Flk-1/KDR, PDGFRβ, and FGFR1 with IC50 values of 2.1, 0.008, and 1.2 μM, respectively. As a potent anti-angiogenic and anti-tumor compound, (Z) -Orantinib ((Z) -SU6668) induces significant regression in established tumors. (Z) -Orantinib serves as a valuable tool for investigating tumor angiogenesis inhibition mechanisms, tumor microenvironment regulation, and targeted anti-cancer strategy development, providing highly reliable experimental support for exploring solid tumor drug mechanisms and drug screening.
Smiles
C(=C\1/C=2C(NC1=O)=CC=CC2)\C3=C(C)C(CCC(O)=O)=C(C)N3
Molecular Formula
C18H18N2O3
Molecular Weight
310.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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