Products for Research Use Only
RegisterLogin

AG-10

CAT: 0931-T9447-03Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T9447-03Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1446711-81-4
Target
Others
Related Pathways
Others
Purity
0.9978
Bioactivity
AG-10 (Acoramidis) is an orally active and selective kinetic stabilizer of TTR (transthyretin) . AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis.
Smiles
O(CCCC=1C(C)=NNC1C)C2=CC(C(O)=O)=CC=C2F
Molecular Formula
C15H17FN2O3
Molecular Weight
292.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Acoramidis

Acoramidis is a small molecule stabilizer of transthyretin (TTR) for use in patients with TTR amyloidosis. Similar to the previously developed [tafamidis], acoramidis is used to stabilize TTR in its tetrameric form, preventing the formation of amyloidogenic monomers and the progression of amyloidosis. Although they share a mechanism of action, acoramidis is more selective for TTR and is a more potent stabilizer when compared to tafamidis. Acoramidis has been in development since at least 2013. It was brought to market by BridgeBio Pharma and approved by the FDA in November 2024 to reduce negative cardiovascular outcomes in patients with cardiomyopathy caused by TTR amyloidosis.

CAS Number1446711-81-4
PubChem CID71464713
IUPAC Name3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid
Molecular FormulaC15H17FN2O3
Molecular Weight292.30
XLogP2.9
Topological Polar Surface Area75.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count21
Formal Charge0
Complexity356
SMILES
CC1=C(C(=NN1)C)CCCOC2=C(C=CC(=C2)C(=O)O)F
InChI
InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
InChIKey
WBFUHHBPNXWNCC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Acoramidis
CAS: 1446711-81-4
CID: 71464713
Formula: C15H17FN2O3
MW: 292.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.30
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass292.12232057
Monoisotopic Mass292.12232057
Topological Polar Surface Area75.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T23659AG 84-10
T69748-01AG-12286
T22025-01AG 045572
T9050-01AG-270
T7493-01AG-13958
T71827-01AG-205
T21784-01AG-370
T26574AG-7404
T4554-01AG 1406
T26571-01AG-1859

Alternative Products

CatalogName
M37629-01AG-10
GTR19200565AG 84-10
sc-213132Tyrphostin AG 10
40-1505-10FAG Mon-coxl-For1; 10 nmols
40-1505-10RAG Mon-coxl-Rev1; 10 nmols
40-1505-10AG Monkey-coxI Genemer; 10 nmols
40-1505-10CAG Monkey-coxI Control DNA; 10 nmols
YP-W11494-01Human AG (AG) ELISA Kit
MBS384155-01AG-1478 (Tyrphostin AG-1478)
VR-AIVH7-AG-10Avian Influenza VirusH7 (AIV H7) AG RapidTestdevice (LS) 10

Popular Products