IQ-3

• Target :

  JNK

• Related Pathways :

  MAPK

• Purity :

  ?98%

• Bioactivity :

  IQ3 is a selective inhibitor of JNK3 (JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively) . IQ 3 inhibits NF-?B/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 ?M, also inhibits TNF-? and IL-6 production in vitro.

• Smiles :

  O=C(ON=C1c2ccccc2-c2nc3ccccc3nc12)c1ccco1

• Molecular Formula :

  C20H11N3O3

• Molecular Weight :

  341.32

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  312538-03-7