(E/Z) -GSK5182

CAT: 0931-T7709-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T7709-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2699724-40-6

Target

Reactive Oxygen Species, Estrogen/progestogen Receptor, Estrogen Receptor/ERR, ROS

Related Pathways

Metabolism, Immunology/Inflammation, NF-κB, Endocrinology/Hormones

Purity

0.9883

Bioactivity

(E/Z) -GSK5182 (GSK5182 (Z/E) ) is a racemic mixture comprising (E) -GSK5182 and (Z) -GSK5182 isomers. It acts as a highly selective and orally active inverse agonist for the estrogen-related receptor γ (ERRγ), demonstrating potency with an IC50 of 79 nM. Additionally, GSK5182 is known to induce the generation of reactive oxygen species (ROS) in hepatocellular carcinoma.

Smiles

CN(C)CCOC1=CC=C(C=C1)C(=C(CCCO)C1=CC=CC=C1)C1=CC=C(O)C=C1

Molecular Formula

C27H31NO3

Molecular Weight

417.54

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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(E/Z) -GSK5182

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