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SGI-7079

CAT: 0931-T6982-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T6982-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1239875-86-5
Target
C-Met/HGFR, FLT, c-RET, Src, TAM Receptor
Related Pathways
Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9926
Bioactivity
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.
Smiles
CN1CCN(CC1)c1ccc(Nc2nc(-c3cccc(CC#N)c3)c3c(C)c[nH]c3n2)cc1F
Molecular Formula
C26H26FN7
Molecular Weight
455.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(3-(2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile
CAS Number1239875-86-5
PubChem CID46870258
IUPAC Name2-[3-[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]acetonitrile
Molecular FormulaC26H26FN7
Molecular Weight455.5
XLogP4.3
Topological Polar Surface Area83.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity719
SMILES
CC1=CNC2=NC(=NC(=C12)C3=CC=CC(=C3)CC#N)NC4=CC(=C(C=C4)N5CCN(CC5)C)F
InChI
InChI=1S/C26H26FN7/c1-17-16-29-25-23(17)24(19-5-3-4-18(14-19)8-9-28)31-26(32-25)30-20-6-7-22(21(27)15-20)34-12-10-33(2)11-13-34/h3-7,14-16H,8,10-13H2,1-2H3,(H2,29,30,31,32)
InChIKey
BCFKACXAIBEPKR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(3-(2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile
CAS: 1239875-86-5
CID: 46870258
Formula: C26H26FN7
MW: 455.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight455.5
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass455.22337202
Monoisotopic Mass455.22337202
Topological Polar Surface Area83.9 Ų
Heavy Atom Count34
Formal Charge0
Complexity719
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-12964-01SGI-7079
A15864-500SGI-7079 500mg
A15864-25SGI-7079 25mg
A15864-5SGI-7079 5mg
A15864-2SGI-7079 2mg
A15864-100SGI-7079 100mg
A15864-50SGI-7079 50mg
A15864-10SGI-7079 10mg
A15864-10mM-DSGI-7079 10mM * 1mL in DMSO
MBS5779370AH 7079

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