Pexmetinib

• Target:

  P38 MAPK|||Autophagy|||Tie-2

• Related Pathways:

  Autophagy|||MAPK|||Tyrosine Kinase/Adaptors

• Purity:

  0.9966

• Bioactivity:

  Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor studied in acute myeloid leukemia and inhibits osteoclastogenesis and breast cancer-induced osteolysis via the P38/STAT3 signaling pathway.

• Smiles:

  Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)ccc1Oc1ccc2n(CCO)ncc2c1)C(C)(C)C

• Molecular Formula:

  C31H33FN6O3

• Molecular Weight:

  556.63

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  945614-12-0