Pexmetinib (Standard)

• Description:

  Pexmetinib (Standard) is the analytical standard of Pexmetinib. This product is intended for research and analytical applications. Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.

• UNSPSC:

  12352100

• Target:

  Autophagy; p38 MAPK; Reference Standards; Tie

• Related Pathways:

  Autophagy; MAPK/ERK Pathway; Others; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5

• Molecular Formula:

  C31H33FN6O3

• Molecular Weight:

  556.63

• References & Citations:

  [1]Bachegowda L, et al. Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia. Cancer Res. 2016 Aug 15;76 (16) :4841-4849.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [945614-12-0]