Leupeptin

CAT: 0931-T6564LSize: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T6564LSize:25 mg

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CAS Number

24365-47-7

Target

Virus Protease, Cysteine Protease, Serine Protease

Related Pathways

Microbiology/Virology, Proteases/Proteasome

Bioactivity

Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C) . Leupeptin does not inhibit α-chymotrypsin or thrombin.

Smiles

CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCNC(N)=N)C=O

Molecular Formula

C20H38N6O4

Molecular Weight

426.562

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Leupeptin Ac-LL

Leupeptin Ac is a dipeptide.

CAS Number	24365-47-7
PubChem CID	5284408
IUPAC Name	(2S)-2-acetamido-N-[(2S)-1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
Molecular Formula	C20H38N6O4
Molecular Weight	426.6
XLogP	0.4
Topological Polar Surface Area	169
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	14
Heavy Atom Count	30
Formal Charge	0
Complexity	602

SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C

InChI

InChI=1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15?,16-,17-/m0/s1

InChIKey

GDBQQVLCIARPGH-BSOSBYQFSA-N

Chemical Structure

2D Structure

CAS: 24365-47-7

CID: 5284408

Formula: C20H38N6O4

MW: 426.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	426.6
XLogP3	0.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	14
Exact Mass	426.29545371
Monoisotopic Mass	426.29545371
Topological Polar Surface Area	169 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	602
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
N-1000.0025	Leupeptin
281320-01	Leupeptin Trifluoroacetate
41200020-1	Leupeptin Hemisulfate

Leupeptin

Chemical Information

Alternative Products

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