Indoximod

• Target:

  Indoleamine 2,3-Dioxygenase (IDO) |||IDO

• Related Pathways:

  Metabolism

• Purity:

  0.9955

• Bioactivity:

  Indoximod (NLG-8189) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.

• Smiles:

  Cn1cc(C[C@@H](N)C(O)=O)c2ccccc12

• Molecular Formula:

  C12H14N2O2

• Molecular Weight:

  218.25

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  110117-83-4