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Galeterone

CAT: 0931-T6509-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T6509-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
851983-85-2
Target
Cytochromes P450, Androgen Receptor
Related Pathways
Metabolism, Endocrinology/Hormones
Purity
0.99773
Bioactivity
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17, 20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.
Smiles
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CC=C2n1cnc2ccccc12
Molecular Formula
C26H32N2O
Molecular Weight
388.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
FT65187-01Galeterone
CS-T-103430Galeterone-d4
HY-70006AGaleterone (hydrochloride)

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