FXR antagonist 1

• Target :

  Others|||FXR

• Related Pathways :

  Metabolism|||Others

• Bioactivity :

  FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 ?M. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation of hepatic FXR. FXR antagonist 1 can improve liver steatosis, inflammation and fibrosis in the NASH (non-alcoholic steatohepatitis) model and can be used to study NASH.

• Smiles :

  C(NCC(O)=O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@H](OC(CCC)=O)CC5)[H])[H])[H])([C@H]([C@H](C)C)CC2)[H]

• Molecular Formula :

  C36H59NO5

• Molecular Weight :

  585.86

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2295804-68-9