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K20

CAT: 0931-T63823-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63823-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Apoptosis, Ras, ERK, Others, Kras
Related Pathways
MAPK, Apoptosis, Others, GPCR/G Protein
Bioactivity
K20 is a potent and selective inhibitor of KRas G12C (IC50: 1.16 nM) . In H358 cells, K20 demonstrates an anticancer effect with an IC50 value of 0.78 μM and inhibits the growth of NCI-H358 tumor cells (TGI: 41%) without significant toxicity. K20 reduces the phosphorylation level of Erk, leading to apoptosis.
Molecular Formula
C24H20Cl2F4N4O2
Molecular Weight
543.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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