EGFR-IN-60

CAT: 0931-T63769-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T63769-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2699877-43-3

Target

Apoptosis, EGFR, Others

Related Pathways

Apoptosis, JAK/STAT signaling, Angiogenesis, Others, Tyrosine Kinase/Adaptors

Bioactivity

EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM) . IN-60 inhibited H1975 cells carrying the EGFRT790M mutation (IC50: 1.32 μM) and A431 cells overexpressing EGFRWT (IC50: 4.96 μM) . EGFR-IN-60 increased the Bax/Bcl-2 ratio, which induced apoptosis induction and cell death.

Smiles

O=C1C=2C(C3=C(NC2CC(C)(C)C1)N=CN(N=CC4=CC=C(N(C)C)C=C4)C3=N)C5=C(Cl)C(Cl)=CC=C5

Molecular Formula

C28H28Cl2N6O

Molecular Weight

535.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-147826	EGFR-IN-60
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EGFR-IN-60

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