BMS-309403 sodium

CAT: 0931-MF-0153578Size: 500 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0153578Size:500 mg
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CAS Number
2802523-05-1
Target
Others|||FABP
Related Pathways
Others|||Metabolism
Bioactivity
BMS-309403 sodium is a potent, orally active, selective inhibitor of adipocyte fatty acid binding protein (FABP4, aP2), with inhibitory constants (Ki) of <2 nM for FABP4, 250 nM for FABP3, and 350 nM for FABP5. It competitively binds to the fatty-acid-binding pocket of the protein, impeding the attachment of endogenous fatty acids. This compound enhances endothelial function in apolipoprotein E-deficient mice and cultured human endothelial cells, underlining its potential therapeutic benefits [1] [2] [3].
Smiles
[Na+].CCc1c(c(nn1-c1ccccc1-c1cccc(OCC([O-])=O)c1)-c1ccccc1)-c1ccccc1
Molecular Formula
C31H25N2NaO3
Molecular Weight
496.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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