Wortmannin

CAT: 0931-T6283-02Size: 2 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T6283-02Size:2 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

19545-26-7

Target

Antibiotic, PI3K, Serine/threonin kinase, Autophagy, ATM/ATR, PLK, DNA-PK

Related Pathways

Metabolism, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Autophagy, DNA Damage/DNA Repair, Microbiology/Virology

Purity

0.9977

Bioactivity

Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.

Smiles

C[C@@]12C3=C([C@]4([C@](C)(C[C@H]3OC(C)=O)C(=O)CC4)[H])C(=O)C5=C1C(C(=O)O[C@@H]2COC)=CO5

Molecular Formula

C23H24O8

Molecular Weight

428.43

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Wortmannin

Wortmannin is a delta-lactone, an organic heteropentacyclic compound, a cyclic ketone and an acetate ester. It has a role as a radiosensitizing agent, an anticoronaviral agent, a geroprotector, an antineoplastic agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, a Penicillium metabolite and an autophagy inhibitor.

CAS Number	19545-26-7
PubChem CID	312145
IUPAC Name	[(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate
Molecular Formula	C23H24O8
Molecular Weight	428.4
XLogP	1.2
Topological Polar Surface Area	109
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	31
Formal Charge	0
Complexity	921

SMILES

CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C

InChI

InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChIKey

QDLHCMPXEPAAMD-QAIWCSMKSA-N

Chemical Structure

2D Structure

CAS: 19545-26-7

CID: 312145

Formula: C23H24O8

MW: 428.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	428.4
XLogP3	1.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	428.14711772
Monoisotopic Mass	428.14711772
Topological Polar Surface Area	109 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	921
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
XW176913-01	Wortmannin

Wortmannin

Chemical Information

Alternative Products

Popular Products