GGTI-286

• Target :

  Others|||Ras

• Related Pathways :

  Others|||MAPK|||GPCR/G Protein

• Bioactivity :

  GGTI-286 is a potent, cell permeable GGTase I inhibitor (IC50: 2 ?M) . GGTI-286 inhibits Rap1A geranylation in NIH3T3 cells (IC50: 2 ?M) more potently than H-Ras farnesylation (IC50>30 ?M) . Ras4B stimulation (IC50: 1 ?M) .

• Smiles :

  C(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C2=CC=CC=C2

• Molecular Formula :

  C23H31N3O3S

• Molecular Weight :

  429.58

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  171744-11-9