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XT2

CAT: 0931-T61599-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61599-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2582816-37-1
Target
Others, NF-κB
Related Pathways
Others, NF-κB
Bioactivity
XT2 is a highly potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK), exhibiting an IC50 of 9.1 nM. It effectively suppresses the upregulation of ALT, a vital biomarker for acute liver injury, induced by CCl4. Additionally, XT2 significantly decreases immune cell infiltration into the damaged liver tissue. As a result, XT2 holds immense potential in liver inflammatory disease research [1].
Smiles
C[C@@](O)(C#Cc1ccc(F)c(c1)-c1c[nH]c2cnc(N)nc12)c1nccs1
Molecular Formula
C19H14FN5OS
Molecular Weight
379.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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