GSK-1482160

CAT: 0931-T61025-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T61025-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1001389-72-5

Target

P2X Receptor

Related Pathways

Neuroscience, Membrane transporter/Ion channel

Purity

0.9987

Bioactivity

GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows excellent in vitro potency (in functional and electrophysiological assays at recombinant and naive P2X7 receptors across multiple species including humans) and cross-target selectivity.

Smiles

CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F

Molecular Formula

C14H14ClF3N2O2

Molecular Weight

334.72

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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BA6853-10	GSK-1482160
HY-123382	GSK-1482160 (isomer)
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MBS131519	GSK369796 (GSK-369796, GSK 369796)
A3450-5.1	GSK-923295
BA4485-5.1	GSK-25
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GSK-1482160

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