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Cefoselis (sulfate)

CAT: 0804-HY-B0186B-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0186B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cefoselis sulfate (FK-037), the fourth gen-eration of cephalosporin, is a β-lactam antibiotic. Cefoselis sulfate exhibits good activity against a wide range of Gram-positive and Gram-negative organisms. Cefoselis sulfate penetrates the blood-brain barrier[1][2][3].
CAS Number
122841-12-7
Product Name Alternative
FK-037
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Cefoselis-sulfate.html
Purity
99.36
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic)
Smiles
O=C(C(N12)=C(CN3N(CCO)C(C=C3)=N)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O.O=S(O)(O)=O
Molecular Formula
C19H24N8O10S3
Molecular Weight
620.64
Precautions
H302, H312, H332
References & Citations
[1]ZHU, D., et al., In vitro activities of cefoselis compared to β-lactams and other antibacterial agents aganst gram-positive and gram-negative clinical isolates. Chinese Journal of Infection and Chemotherapy, 2011. 4: p. 002.|[2]King, A., L. Bethune, and I. Phillips, The Comparative In Vitro Activity of FK-037 (Cefoselis), a New Broad-Spectrum Cephalosporin. Clin Microbiol Infect, 1995. 1 (1) : p. 13-17.|[3]K Ohtaki, et al. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm (Vienna) . 2004 Dec;111 (12) :1523-35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β-lactam

Chemical Information

Cefoselis Sulfate

Cefoselis sulfate is an azaheterocycle sulfate salt. It is functionally related to a member of cefoselis.

CAS Number122841-12-7
PubChem CID9830519
IUPAC Name(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[2-(2-hydroxyethyl)-3-iminopyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;sulfuric acid
Molecular FormulaC19H24N8O10S3
Molecular Weight620.6
Topological Polar Surface Area334
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count17
Rotatable Bond Count9
Heavy Atom Count40
Formal Charge0
Complexity1100
SMILES
CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.OS(=O)(=O)O
InChI
InChI=1S/C19H22N8O6S2.H2O4S/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28;1-5(2,3)4/h2-3,8,13,17,20,28H,4-7H2,1H3,(H2,21,22)(H,23,29)(H,31,32);(H2,1,2,3,4)/b20-11?,24-12-;/t13-,17-;/m1./s1
InChIKey
LZOLCSVRFKCSEM-ZQCAECPKSA-N
Chemical Structure
2D Structure
2D structure of Cefoselis Sulfate
CAS: 122841-12-7
CID: 9830519
Formula: C19H24N8O10S3
MW: 620.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight620.6
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count17
Rotatable Bond Count9
Exact Mass620.07775251
Monoisotopic Mass620.07775251
Topological Polar Surface Area334 Ų
Heavy Atom Count40
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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CatalogName
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A10189-50Cefoselis sulfate 50mg
A10189-10Cefoselis sulfate 10mg
A10189-25Cefoselis sulfate 25mg
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