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(E/Z) -Rigosertib sodium

CAT: 0931-T6070-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T6070-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1225497-78-8
Target
PLK
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9982
Bioactivity
ON-01910 is a non-ATP-competitive PLK1 inhibitor (IC50 of 9 nM, in a cell-free assay) . It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Smiles
[Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1
Molecular Formula
C21H24NNaO8S
Molecular Weight
473.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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