Rigosertib

• CAS Number :

  592542-59-1

• Target :

  PI3K|||PLK|||FLT|||Apoptosis|||PDGFR|||Src|||CDK|||Bcr-Abl

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling|||Apoptosis|||Angiogenesis|||Cytoskeletal Signaling

• Purity :

  0.9953

• Bioactivity :

  Rigosertib (ON-01910) is a selective, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor. As a selective anti-cancer agent, Rigosertib induces apoptosis by inhibiting the PI3 kinase/Akt pathway, promotes histone H2AX phosphorylation, and induces G2/M arrest in the cell cycle.

• Smiles :

  C(=C/S(CC1=CC(NCC(O)=O)=C(OC)C=C1)(=O)=O)\C2=C(OC)C=C(OC)C=C2OC

• Molecular Formula :

  C21H25NO8S

• Molecular Weight :

  451.49

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C