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Rigosertib

CAT: 0931-T16750-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T16750-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
592542-59-1
Target
PI3K, PLK, FLT, Apoptosis, PDGFR, Src, CDK, Bcr-Abl
Related Pathways
Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Apoptosis, Angiogenesis, Cytoskeletal Signaling
Purity
0.9953
Bioactivity
Rigosertib (ON-01910) is a selective, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor. As a selective anti-cancer agent, Rigosertib induces apoptosis by inhibiting the PI3 kinase/Akt pathway, promotes histone H2AX phosphorylation, and induces G2/M arrest in the cell cycle.
Smiles
C(=C/S(CC1=CC(NCC(O)=O)=C(OC)C=C1)(=O)=O)\C2=C(OC)C=C(OC)C=C2OC
Molecular Formula
C21H25NO8S
Molecular Weight
451.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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