URMC-099

• Target :

  Syk|||Src|||Trk receptor|||IGF-1R|||Bcr-Abl|||CDK|||SGK|||ROCK|||VEGFR|||DNA Alkylation|||MLK|||LRRK2|||Aurora Kinase|||c-Met/HGFR|||MEK|||Autophagy

• Related Pathways :

  Stem Cells|||DNA Damage/DNA Repair|||Metabolism|||Autophagy|||Cytoskeletal Signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||MAPK|||Cell Cycle/Checkpoint

• Purity :

  0.9998

• Bioactivity :

  URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM) .

• Smiles :

  CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1

• Molecular Formula :

  C27H27N5

• Molecular Weight :

  421.54

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1229582-33-5