RP-6685

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

• Purity:

  0.9965

• Bioactivity:

  RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Pol?), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Pol?. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].

• Smiles:

  Nc1ccc(nn1)C#CCN(C(=O)Cc1ncc(cc1C(F)(F)F)C(F)(F)F)c1ccc(F)cc1

• Molecular Formula:

  C22H14F7N5O

• Molecular Weight:

  497.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2832047-80-8