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RP-6685

CAT: 0931-T60187-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T60187-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2832047-80-8
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9965
Bioactivity
RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].
Smiles
Nc1ccc(nn1)C#CCN(C(=O)Cc1ncc(cc1C(F)(F)F)C(F)(F)F)c1ccc(F)cc1
Molecular Formula
C22H14F7N5O
Molecular Weight
497.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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