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RU.521

CAT: 0931-T5486-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T5486-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2262452-06-0
Target
DNA, cGAS
Related Pathways
Immunology/Inflammation, DNA Damage/DNA Repair
Purity
0.9982
Bioactivity
RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse: IC50=0.11 μM), (human: IC50=2.94 μM) . RU.521 is an inhibitor of the receptor activated by dsDNA (IC50=700 nM) . RU.521 inhibits cGAS-mediated interferon upregulation. RU.521 reduces constitutive interferon expression in macrophages derived from a mouse model of Aicardi-Goutieres syndrome.
Smiles
Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1
Molecular Formula
C19H12Cl2N4O3
Molecular Weight
415.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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