RU.521

• Target :

  DNA|||cGAS

• Related Pathways :

  Immunology/Inflammation|||DNA Damage/DNA Repair

• Purity :

  0.9982

• Bioactivity :

  RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse: IC50=0.11 ?M), (human: IC50=2.94 ?M) . RU.521 is an inhibitor of the receptor activated by dsDNA (IC50=700 nM) . RU.521 inhibits cGAS-mediated interferon upregulation. RU.521 reduces constitutive interferon expression in macrophages derived from a mouse model of Aicardi-Goutieres syndrome.

• Smiles :

  Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1

• Molecular Formula :

  C19H12Cl2N4O3

• Molecular Weight :

  415.23

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2262452-06-0