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AZ304

CAT: 0931-T5172-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T5172-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
942507-42-8
Target
Raf, Autophagy, c-Fms, p38 MAPK
Related Pathways
Autophagy, MAPK, Tyrosine Kinase/Adaptors
Purity
0.9983
Bioactivity
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, effectively inhibiting BRAF (WT), BRAF (V600E), and wild-type CRAF [IC50s: 79/38/68 nM].
Smiles
COc1ccc2c(Nc3cc(NC(=O)c4cccc(c4)C(C)(C)C#N)ccc3C)ncnc2c1
Molecular Formula
C27H25N5O2
Molecular Weight
451.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
CAS Number942507-42-8
PubChem CID16202218
IUPAC Name3-(2-cyanopropan-2-yl)-N-[3-[(7-methoxyquinazolin-4-yl)amino]-4-methylphenyl]benzamide
Molecular FormulaC27H25N5O2
Molecular Weight451.5
XLogP5.2
Topological Polar Surface Area99.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity749
SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=NC=NC4=C3C=CC(=C4)OC
InChI
InChI=1S/C27H25N5O2/c1-17-8-9-20(31-26(33)18-6-5-7-19(12-18)27(2,3)15-28)13-23(17)32-25-22-11-10-21(34-4)14-24(22)29-16-30-25/h5-14,16H,1-4H3,(H,31,33)(H,29,30,32)
InChIKey
NGWQZRWVYYFTHC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
CAS: 942507-42-8
CID: 16202218
Formula: C27H25N5O2
MW: 451.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight451.5
XLogP35.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass451.20082506
Monoisotopic Mass451.20082506
Topological Polar Surface Area99.9 Ų
Heavy Atom Count34
Formal Charge0
Complexity749
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3842200-01AZ304
A17225-100AZ304 100mg
A17225-50AZ304 50mg
A17225-10AZ304 10mg
A17225-25AZ304 25mg
A17225-5AZ304 5mg
A17225-10mM-DAZ304 10mM * 1mL in DMSO

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