Avapritinib

• CAS Number :

  1703793-34-3

• Target :

  PDGFR|||c-Kit

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Angiogenesis

• Purity :

  0.997

• Bioactivity :

  Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.

• Smiles :

  Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1

• Molecular Formula :

  C26H27FN10

• Molecular Weight :

  498.56

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C