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Protostemonine

CAT: 0931-T4S0083Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T4S0083Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
27495-40-5
Target
Others
Related Pathways
Others
Bioactivity
1. Protostemonine has anti-inflammatory activity, it effectively attenuates LPS-induced inflammatory responses in vitro and in vivo; the beneficial effects are associated with the decreased phosphorylation of MAPK and AKT and the reduced expression of pro-inflammatory mediators, such as iNOS, NO and cytokines. 2. Protostemonine shows strong nematicidal activity against Panagrellus redivevus, with the IC50 value of 0.10 uM. 3. Protostemonine attenuates LPS/GalN-induced acute liver failure and upregulating HO-1 expression is implicated in its hepatoprotective activity. 4. Protostemonine shows significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration.
Smiles
COC1=C(C)C(=O)OC\1=C1/O[C@@H]2CCCN3[C@@H](CC[C@H]3[C@H]2[C@@H]1C)[C@@H]1C[C@H](C)C(=O)O1
Molecular Formula
C23H31NO6
Molecular Weight
417.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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