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Lambertianic acid

CAT: 0804-HY-127057Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-127057Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
4966-13-6
UNSPSC Description
Lambertianic acid is a bioactive diterpene with anti-allergic, antibacterial and anticancer activities. Lambertianic acid decreases androgen receptor protein levels, cellular and secretory levels of prostate-specific antigen. Lambertianic acid also suppresses cell proliferation by inducing G1 arrest, downregulating CDK4/6 and cyclin D1, activating p53, p21 and p27. Lambertianic acid induces Apoptosis and the expression of related proteins, including cleaved caspase-3/9, c-PARP and BAX, and inhibited BCl-2. Lambertianic acid is promising for research of prostate cancer[1].
Target Antigen
Androgen Receptor; Apoptosis; Bcl-2 Family; Caspase; CDK; MDM-2/p53; PARP
Type
Natural Products
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lambertianic-acid.html
Smiles
C[C@@]12[C@](CCC([C@@H]2CCC3=COC=C3)=C)([H])[C@](C)(CCC1)C(O)=O
Molecular Weight
316.43
References & Citations
[1]Lee MS, et al. Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells. Int J Mol Sci. 2016 Jul 7;17(7):1066.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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