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NS309

CAT: 0931-T4612-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T4612-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
18711-16-5
Target
Potassium Channel, EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Membrane transporter/Ion channel
Purity
0.9755
Bioactivity
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels) . It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.
Smiles
ON=C1C(=O)Nc2c1ccc(Cl)c2Cl
Molecular Formula
C8H4Cl2N2O2
Molecular Weight
231.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(Z)-6,7-dichloro-3-(hydroxyimino)indolin-2-one

See also: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime (annotation moved to).

CAS Number18711-16-5
PubChem CID135502903
IUPAC Name6,7-dichloro-3-nitroso-1H-indol-2-ol
Molecular FormulaC8H4Cl2N2O2
Molecular Weight231.03
XLogP3.2
Topological Polar Surface Area65.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count14
Formal Charge0
Complexity241
SMILES
C1=CC(=C(C2=C1C(=C(N2)O)N=O)Cl)Cl
InChI
InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,11,13H
InChIKey
ROBYKNONIPZMTK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (Z)-6,7-dichloro-3-(hydroxyimino)indolin-2-one
CAS: 18711-16-5
CID: 135502903
Formula: C8H4Cl2N2O2
MW: 231.03
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight231.03
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass229.9649828
Monoisotopic Mass229.9649828
Topological Polar Surface Area65.5 Ų
Heavy Atom Count14
Formal Charge0
Complexity241
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A3668-5NS309

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