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NS309

CAT: 0013-GTR19159945-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159945-01Size:1 g
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Description
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels) . It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.
CAS Number
18711-16-5
Product Name Alternative
NS309 | NS-309 | NS 309
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 50 mg/mL; 216.41 mM
Smiles
Clc2ccc1c (NC (=O) C1=NO) c2Cl
Molecular Formula
C8H4Cl2N2O2
Molecular Weight
231.04
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(Z) -6,7-dichloro-3- (hydroxyimino) indolin-2-one

Alternative Products

CatalogName
A3668-5NS309

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