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Licochalcone D

CAT: 0931-T4518-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T4518-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
144506-15-0
Target
NF-?B|||Apoptosis|||Reactive Oxygen Species|||ERK|||ROS
Related Pathways
Metabolism|||Apoptosis|||Immunology/Inflammation|||NF-?B|||MAPK
Purity
0.999
Bioactivity
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. Licochalcone D has anti-inflammatory activity, it shows suppression ability of nitric oxide (NO) production. Licochalcone D has anti-allergic activity, it suppresses degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.
Smiles
COc1c(O)c(O)ccc1\C=C\C(=O)c1ccc(O)c(CC=C(C)C)c1
Molecular Formula
C21H22O5
Molecular Weight
354.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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