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EN460

CAT: 0804-HY-12837-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12837-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation[1].
CAS Number
496807-64-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endoplasmic Reticulum Oxidoreductase 1 (ERO1)
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/EN460.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(F)(F)C1=NN(C2=CC(C(O)=O)=C(Cl)C=C2)C(/C1=C\C3=CC=C(C4=CC=CC=C4)O3)=O
Molecular Formula
C22H12ClF3N2O4
Molecular Weight
460.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Blais JD, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285 (27) :20993-1003.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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