GSK 2833503A

• Target:

  Others|||TRP/TRPV Channel

• Related Pathways:

  Membrane transporter/Ion channel|||Others

• Bioactivity:

  GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively) . GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cellsin vitroand in cardiomyocytes.

• Smiles:

  C(=O)(C=1N=C(NC2=C(F)C=C(Cl)C=C2)SC1C)N3[C@@H](C)[C@@H](C)CCC3

• Molecular Formula:

  C18H21ClFN3OS

• Molecular Weight:

  381.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1366234-01-6