FTI 277 TFA

• Target:

  Others|||Apoptosis|||Ras|||Transferase

• Related Pathways:

  MAPK|||Apoptosis|||Metabolism|||Others

• Bioactivity:

  FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM) . Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10?M respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

• Smiles:

  OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1

• Molecular Formula:

  C24H30F3N3O5S2

• Molecular Weight:

  561.64

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1217447-06-7