Products for Research Use Only

BODIPY FL VH032

CAT: 0931-T41171-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T41171-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2770675-66-4
Target
Others
Related Pathways
Others
Bioactivity
BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of VHL ligands. BODIPY FL VH032 consists of a derivative of von Hippel-Lindau (VHL) ligand VH 032 and a fluorophore BODIPY FL (with excitation peak at 504 nm and emission peak at 520 nm), joined by a polyethylene glycol (PEG) 4 linker. The BODIPY FL VH032 VHL TR-FRET signal is stable through the 90 - 300 min incubation time, and theTR-FRET binding assay is sensitive, selective and resistant to assay interference. BODIPY FL VH032 also exhibits high VHL affinity in a fluorescence polarization (FP) assay. Excitation maximum ~ 504 nm; emission maximum ~ 520 nm.
Smiles
O=C(N1[C@@H](CC(C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOCCNC(CCC4=CC=C(C=C5C(C)=C6)N4[B-](F)(F)[N+]5=C6C)=O)=O
Molecular Formula
C46H62BF2N7O9S
Molecular Weight
937.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C