EM 163

• Target:

  P38 MAPK|||MyD88|||IL Receptor|||TNF|||IFNAR

• Related Pathways:

  Immunology/Inflammation|||Apoptosis|||MAPK

• Purity:

  0.9907

• Bioactivity:

  EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB) . EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1? on chemically induced long-term potentiation (LTP) -triggered protein synthesis.

• Smiles:

  N([C@H](C(=O)N1CCCC1)C(C)C)(C(=O)C2=C[N+](C)=C(C(N([C@H](C(=O)N3CCCC3)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)CCCC5=CC=CC=C5.[I-]

• Molecular Formula:

  C44H60IN5O4

• Molecular Weight:

  849.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1206480-93-4