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EM 163

CAT: 0931-T41142-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T41142-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1206480-93-4
Target
P38 MAPK, MyD88, IL Receptor, TNF, IFNAR
Related Pathways
Immunology/Inflammation, Apoptosis, MAPK
Purity
0.9907
Bioactivity
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB) . EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP) -triggered protein synthesis.
Smiles
N([C@H](C(=O)N1CCCC1)C(C)C)(C(=O)C2=C[N+](C)=C(C(N([C@H](C(=O)N3CCCC3)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)CCCC5=CC=CC=C5.[I-]
Molecular Formula
C44H60IN5O4
Molecular Weight
849.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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