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Moxonidine hydrochloride

CAT: 0931-T40869-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T40869-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
75536-04-8
Target
LDLR, Others, Imidazoline Receptor, Adrenergic Receptor
Related Pathways
Others, GPCR/G Protein, Metabolism, Neuroscience
Bioactivity
Moxonidine Hydrochloride serves as a selective agonist for the imidazoline receptor subtype 1 and functions as an antihypertensive agent. It primarily acts within the central nervous system and demonstrates a significant preference for I1 imidazoline receptors over α2-adrenoceptors, with a 40-fold higher affinity. This compound effectively reduces stimulated norepinephrine overflow, indicating its potent efficacy. Despite similar agents like AGN192403 targeting the same receptor, moxonidine's dose-response efficacy remains unaffected. Its ability to lower blood pressure and reduce heart rate is distinctly mediated through imidazoline receptors, reliant on well-preserved noradrenergic pathways within the rostral ventrolateral medulla (RVLM) . This interaction is potentially linked to a specific 42 kDa imidazoline receptor protein, emphasizing its unique mechanism of action compared to other drugs like clonidine.
Smiles
Cl.ClC=1N=C(N=C(OC)C1NC2=NCCN2)C
Molecular Formula
C9H13Cl2N5O
Molecular Weight
278.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Moxonidine hydrochloride
CAS Number75536-04-8
PubChem CID11231255
IUPAC Name4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine;hydrochloride
Molecular FormulaC9H13Cl2N5O
Molecular Weight278.14
Topological Polar Surface Area71.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity275
SMILES
CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC.Cl
InChI
InChI=1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
InChIKey
ZZPAWQYZQVUVHX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Moxonidine hydrochloride
CAS: 75536-04-8
CID: 11231255
Formula: C9H13Cl2N5O
MW: 278.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight278.14
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass277.0497154
Monoisotopic Mass277.0497154
Topological Polar Surface Area71.4 Ų
Heavy Atom Count17
Formal Charge0
Complexity275
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS387812-01Moxonidine Hydrochloride
HY-B0374A-01Moxonidine (hydrochloride)
HY-B0374AR-01Moxonidine (hydrochloride) (Standard)
A13416-50Moxonidine Hydrochloride 50mg
A13416-10Moxonidine Hydrochloride 10mg
A13416-25Moxonidine Hydrochloride 25mg
A13416-5Moxonidine Hydrochloride 5mg
HY-B0374ASMoxonidine-13C, d3 (hydrochloride)
A4080-5.1Moxonidine

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